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KMID : 0191120150300010054
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Journal of Korean Medical Science
2015 Volume.30 No. 1 p.54 ~ p.59
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Three-month Treatment Response and Exacerbation in Chronic Obstructive Pulmonary Disease
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Lee Jung-Su
Rhee Chin-Kook
Yoo Kwang-Ha
Lee Ji-Hyun
Yoon Ho-Il
Kim Tae-Hyung
Kim Woo-Jin
Lee Jin-Hwa
Lim Seong-Yong
Park Tai-Sun
Lee Jae-Seung
Lee Sei-Won
Lee Sang-Do
Oh Yeon-Mok
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Abstract
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The aim of this study was to investigate relationships between acute exacerbation and Forced Expiratory Volume 1 second (FEV1) improvement after treatment with combined long-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) in patients with chronic obstructive pulmonary disease (COPD). A total of 137 COPD patients were classified as responders or nonresponders according to FEV1 improvement after 3 months of LABA/ICS treatment in fourteen referral hospitals in Korea. Exacerbation occurrence in these two subgroups was compared over a period of 1 yr. Eighty of the 137 COPD patients (58.4%) were classified as responders and 57 (41.6%) as nonresponders. Acute exacerbations occurred in 25 patients (31.3%) in the responder group and in 26 patients (45.6%) in the nonresponder group (P=0.086). FEV1 improvement after LABA/ICS treatment was a significant prognostic factor for fewer acute exacerbations in a multivariate Cox proportional hazard model adjusted for age, sex, FEV1, smoking history, 6 min walk distance, body mass index, exacerbation history in the previous year, and dyspnea scale.Three-month treatment response to LABA/ICS might be a prognostic factor for the occurrence of acute exacerbation in COPD patients.
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KEYWORD
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Pulmonary Disease, Chronic Obstructive, Forced Expiratory Volume, Disease Progression
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